Search results for "target [deuteron]"

showing 9 items of 159 documents

Non-target and biological diversity risk assessment

2008

This chapter discusses the following procedures for risk assessment in Bt cotton using the non-target risk assessment model developed by scientists of the GMO ERA Project ("International Project on GMO Environmental Risk Assessment Methodologies", which is a continuation of the GMO Guidelines Project, which was launched by scientists of the International Organization for Biological Control Global Working Group on "Transgenic Organisms in Integrated Pest Management and Biological Control"): (1) identify relevant functional groups of biological diversity associated with adverse effects, (2) list and prioritize species or ecological processes, (3) identify potential exposure pathways and adver…

nontarget effectgenetic engineeringnontarget organismgenetic transformationrisk assessmentcottontransgenic plant
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Painful oral aphthous-like lesions in patient with kidney cancer after target therapy and bisphosphonate administration: a case report of adverse dru…

2015

Aim. Tyrosine kinase inhibitors (TKIs) targeting tu- mor angiogenesis and mammalian target of rapamycin inhibitors (mTOR) are indicated for the management of several cancer types, as for renal cell carcinoma (RCC). Oral ulcerations are reported as common adverse drug reactions of mTOR inhibitors and are currently classified as mTOR inhibitor associated stomatitis (mIAS). Interestingly, these lesions appear as aphthous-like stoma- titis rather than the mucositis seen with chemotherapy agent. Case report. A 49 years old male patient underwent to the left radical nephrectomy in May 2014 for clear RCC. From July to October 2014 he was treated with Pazopanib, a tyrosine kinase inhibitor. In Dece…

oral aphthous-like target therapy bisphosphonate adverse drug reactionSettore MED/28 - Malattie Odontostomatologiche
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First observation and study of the K± → π±π0e+e− decay

2018

The NA48/2 experiment at CERN reports the first observation of the K-+/- -> pi(+/-)pi(0)e(+)e(-) decay from an exposure of 1.7 x 10(11) charged kaon decays recorded in 2003-2004. A sample of 4919 candidates with 4.9% background contamination allows the determination of the branching ratio in the full kinematic region, BR(K-+/- -> pi(+/-)pi(0)e(+)e(-)) = (4.24 +/- 0.14) x 10(-6). The study of the kinematic space shows evidence for a structure dependent contribution in agreement with predictions based on chiral perturbation theory. Several P- and CP-violating asymmetries are also evaluated.

rare decayNuclear and High Energy PhysicsChiral perturbation theoryCP violation; Monte-Carlo; searchAstronomy & AstrophysicsSpace (mathematics)quark mixing01 natural sciencesPartícules (Física nuclear)Charged Kaon decaysPhysics Particles & FieldsCharged Kaon decays quark mixing radiative kaon decay chiral perturbation theoryEconomica0202 Atomic Molecular Nuclear Particle And Plasma PhysicsViolació CP (Física nuclear)MONTE-CARLOSEARCH0103 physical sciencesKaon decaysradiative kaon decay010306 general physicsPhysicsScience & Technology010308 nuclear & particles physicsBranching fractionPhysicsKaon decays Chiral Perturbation TheoryAmbientaleK mesonNuclear & Particles PhysicsChiral Perturbation Theorylcsh:QC1-999fixed target experimentPhysics NuclearPhysical SciencesK meson rare decay fixed target experimentCP violationHigh Energy Physics::ExperimentCP VIOLATIONAtomic physicslcsh:PhysicsPhysics Letters B
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FRI0030 Anti-TNF-α Antibody Targeted To Inflamed Synovial Tissue for The Treatment of Rheumatoid Arthritis

2016

Background TNF-α neutralizing molecules represent one of the most efficient therapeutic approaches to control inflammation in rheumatoid arthritis (RA). The widespread distribution in the body induces the inhibition of TNF-α in all the tissues, requesting the use of high dose of this expensive drug. Another problem that has not yet been solved in the management of RA patients is how to reduce and possibly avoid the side effects, particularly the increased risk of common and opportunistic infections, which may be associated with long-term administration of these therapeutic drugs. Objectives The aim of the present investigation was to show that a recombinant protein obtained by fusing a syno…

rheumatoid arthritisPathologymedicine.medical_specialtyImmunologyArthritisInflammationImmunofluorescenceGeneral Biochemistry Genetics and Molecular BiologyRheumatologyIn vivoAdalimumabmedicineImmunology and AllergyNeutralizing antibodyantigen induced arthritismedicine.diagnostic_testbiologybusiness.industrytarget therapyantigen induced arthritirheumatoid arthritimedicine.diseaseRheumatoid arthritisImmunologyrheumatoid arthritis; antigen induced arthritis; target therapy; immunotherapybiology.proteinTumor necrosis factor alphaimmunotherapymedicine.symptombusinessmedicine.drug
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UAV-based hyperspectral monitoring of small freshwater area

2014

Recent development in compact, lightweight hyperspectral imagers have enabled UAV-based remote sensing with reasonable costs. We used small hyperspectral imager based on Fabry-Perot interferometer for monitoring small freshwater area in southern Finland. In this study we shortly describe the utilized technology and the field studies performed. We explain processing pipeline for gathered spectral data and introduce target detection-based algorithm for estimating levels of algae, aquatic chlorophyll and turbidity in freshwater. Certain challenges we faced are pointed out.

ta113hyperspectral imaginguavtarget detectionta1171Hyperspectral imagingPipeline (software)InterferometryGeographyRemote sensing (archaeology)Fabry-Perot interferometerSpectral datafreshwaterta218Remote sensing
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Methods for estimating forest stem volumes by tree species using digital surface model and CIR images taken from light UAS

2012

In this paper we consider methods for estimating forest tree stem volumes by species using images taken from light unmanned aircraft systems (UAS). Instead of using LiDAR and additional multiband imagery a color infrared camera mounted to a light UAS is used to acquire both imagery and the DSM of target area. The goal of this study is to accurately estimate tree stem volumes in three classes. The status of the ongoing work is described and an initial method for delineating and classifying treetops is presented.

ta113precision agriculturebusiness.industryComputer scienceUAVtarget detectionPiezo actuatorsmedical imagingairborneFabry-Perot Interferometerimaging spectrometerTree (data structure)Hyperspectral sensorsLidarRemote sensing (archaeology)Computer visionArtificial intelligencemultispectral image sensorsDigital surfacebusinessTree speciesRemote sensingProceedings of SPIE
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Problem Transformation Methods with Distance-Based Learning for Multi-Target Regression

2020

Multi-target regression is a special subset of supervised machine learning problems. Problem transformation methods are used in the field to improve the performance of basic methods. The purpose of this article is to test the use of recently popularized distance-based methods, the minimal learning machine (MLM) and the extreme minimal learning machine (EMLM), in problem transformation. The main advantage of the full data variants of these methods is the lack of any meta-parameter. The experimental results for the MLM and EMLM show promising potential, emphasizing the utility of the problem transformation especially with the EMLM. peerReviewed

the minimal learning machine (MLM) and the extreme minimal learning machine (EMLM)koneoppiminenemphasizing the utility of the problem transformation especially with the EMLM.Multi-target regression is a special subset of supervised machine learning problems. Problem transformation methods are used in the field to improve the performance of basic methods. The purpose of this article is to test the use of recently popularized distance-based methodsin problem transformation. The main advantage of the full data variants of these methods is the lack of any meta-parameter. The experimental results for the MLM and EMLM show promising potential
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MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…

therapeutic resistance0301 basic medicineCancer ResearchCell SurvivalMAP Kinase Signaling Systempancreatic cancerAntineoplastic AgentsContext (language use)Mechanistic Target of Rapamycin Complex 2mTORC1Mechanistic Target of Rapamycin Complex 1BiologymTORC2BortezomibMice03 medical and health sciencesCell Line TumorPancreatic cancermedicineAnimalsHumansExtracellular Signal-Regulated MAP KinasesMechanistic target of rapamycinPI3K/AKT/mTOR pathwayBenzoxazolesKinaseMTORTOR Serine-Threonine Kinasesmedicine.diseaseddc:3. Good healthPancreatic NeoplasmsPyrimidines030104 developmental biologyOncologybiology.proteinCancer researchCamptothecinTOR Serine-Threonine KinasesPhosphatidylinositol 3-KinaseTranslational TherapeuticsProto-Oncogene Proteins c-aktBiologieCarcinoma Pancreatic Ductal
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Voltammetric determination of platinum in perfusate and blood: Preliminary data on pharmacokinetic study of arterial infusion with oxaliplatin

2012

Abstract Because Platinum Group Elements have found widespread use in catalytic converters in cars and as chemotherapeutic agent, interest in the development of reliable analytical methods is carried out in order to monitor these analita in humans to protect the citizen's health. Considering that information on the levels of many trace elements in biological matrices is scarce and for many non-essential elements, baseline levels in the population, and especially in those particularly exposed to the risk are lacking, in this paper we optimize an analytical method for biological matrices, using a voltammetric technique to measure the concentration of Pt in blood and perfusate. The amount of P…

voltammetryeducation.field_of_studyChromatographyPopulationAnalytical chemistryPtchemistry.chemical_elementBiological materialsAnalytical ChemistryOxaliplatinchemistryPharmacokineticsbloodperfusatemedicineSettore CHIM/01 - Chimica AnaliticaIn patientPlatinumeducationVoltammetrySpectroscopyTarget organmedicine.drugMicrochemical Journal
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